Author

Lingjie Zhang

Sun Yat-sen UniversityORCID 0000-0002-6506-4457Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Haijun WeniD· 3 shared Miles E Tracy· 3 shared Xuemei LuiD· 3 shared Bingjie Chen· 2 shared Chenli LiuiD· 2 shared Chung‐I WuiD· 2 shared Tong Deng· 2 shared Xueyu Liu· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersEvolutionary Biology

Haijun WenORCID

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3 papers

Recent·Most cited

Genomic Evidence for Males of Exceptional Reproductive Output (ERO) in Apes and Humans

Xiaopei Wang, Hongpu Chen, Lingjie Zhang, Mei Hou, Yang Gao, Xuemei Lu, Pengfei Fan, Miles E Tracy, Li-Ying Huang, Haijun Wen, Yongsen Ruan, Shuhua Xu, Chung-I Wu

The paper uses genomic diversity data to estimate the variance ratio of reproductive output in males and females across apes and humans, finding evidence for exceptional reproductive output in some males.

National Science Review · Jun 27, 2025Peer-reviewedEvolutionary Biology

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

Lingjie Zhang, Tong Deng, Zhongqi Liufu, Xiangnyu Chen, Shijie Wu, Xueyu Liu, Changhao Shi, Bingjie Chen, Zheng Hu, Qichun Cai, Chenli Liu, Mengfeng Li, Miles E Tracy, Xuemei Lu, Chung‐I Wu, Haijun Wen

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

eLife · Sep 5, 2024Peer-reviewedEvolutionary Biology

The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)

Lingjie Zhang, Tong Deng, Zhongqi Liufu, Xueyu Liu, Bingjie Chen, Zheng Hu, Chenli Liu, Miles E Tracy, Xuemei Lu, Haijun Wen, Chung‐I Wu

This study develops a theory to identify Cancer Driving Nucleotides (CDNs) by analyzing mutation recurrence across large cancer datasets, finding that mutations recurring at least three times are likely CDNs.

bioRxiv · May 29, 2024Evolutionary Biology