The solid tumor microenvironment changes the hierarchy of CD155 and CD112 receptors, shaping checkpoint blockade outcome
Valentina Carannante, Karl Olofsson, Hanqing Zhang, Niklas Sandström, Jacopo Maria Fontana, Damien Toullec, Grace Turyasingura, Birte Hell, Arnika Kathleen Wagner, Patrick A. Sandoz, Hanna van Ooijen, Andreas Lundqvist, Martin Wiklund, Björn Önfelt
Tumors shape the hierarchy of CD155-CD112 receptors, reducing TIGIT blockade efficacy, while CD226 drives NK infiltration and shows binding plasticity.
bioRxiv · Aug 2, 2026 · PreprintImmunology