Hanna van Ooijen

The paper shows that CD4 T cell surface protein organization predicts response to anti-PD-1 therapy in NSCLC, outperforming protein abundance alone.

Tumors shape the hierarchy of CD155-CD112 receptors, reducing TIGIT blockade efficacy, while CD226 drives NK infiltration and shows binding plasticity.

This study uses molecular pixelation to profile CAR protein organization dynamics in CAR-T therapy, revealing co-localization network remodeling linked to clinical outcomes.

The paper introduces PNA, a DNA-based method to map protein organization and interactions in single cells, revealing abundance, clustering, and colocalization relationships.

This study evaluates a microwell system for isolating individual NK cells, demonstrating its viability and potential for functional screening but noting its limited throughput.

This paper introduces a thermoplastic chip for single-cell immune assays that enables screening and high-resolution imaging of immune cell responses in 2D and 3D cultures.