Author

Karl Olofsson

Science for Life LaboratoryORCID 0000-0002-3976-3430Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Björn ÖnfeltiD· 3 shared Hanna van OoijeniD· 3 shared Niklas SandströmiD· 3 shared Arnika Kathleen WagneriD· 2 shared Hanqing ZhangiD· 2 shared Patrick A. SandoziD· 2 shared Quentin VerroniD· 2 shared Thomas Wilhelm FriskiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

Björn ÖnfeltORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The solid tumor microenvironment changes the hierarchy of CD155 and CD112 receptors, shaping checkpoint blockade outcome

Valentina Carannante, Karl Olofsson, Hanqing Zhang, Niklas Sandström, Jacopo Maria Fontana, Damien Toullec, Grace Turyasingura, Birte Hell, Arnika Kathleen Wagner, Patrick A. Sandoz, Hanna van Ooijen, Andreas Lundqvist, Martin Wiklund, Björn Önfelt

Tumors shape the hierarchy of CD155-CD112 receptors, reducing TIGIT blockade efficacy, while CD226 drives NK infiltration and shows binding plasticity.

bioRxiv · Aug 2, 2026 · PreprintImmunology

Isolation of individual natural killer cells from deep, high-aspect ratio microwell arrays - an evaluative study

Quentin Verron, Niklas Sandström, Hanna van Ooijen, Karolin Guldevall, Karl Olofsson, Thomas Wilhelm Frisk, Björn Önfelt

This study evaluates a microwell system for isolating individual NK cells, demonstrating its viability and potential for functional screening but noting its limited throughput.

bioRxiv · Feb 20, 2025 · PreprintImmunology

A thermoplastic chip for correlative assays combining screening and high-resolution imaging of immune cell responses

Hanna van Ooijen, Quentin Verron, Hanqing Zhang, Patrick A. Sandoz, Thomas Wilhelm Frisk, Valentina Carannante, Karl Olofsson, Arnika Kathleen Wagner, Niklas Sandström, Björn Önfelt

This paper introduces a thermoplastic chip for single-cell immune assays that enables screening and high-resolution imaging of immune cell responses in 2D and 3D cultures.

Cell Reports Methods · Jan 1, 2025Peer-reviewedImmunology