Inhibition of the Dead Box RNA Helicase 3 prevents HIV-1 Tat and cocaine-induced neurotoxicity by targeting microglia activation
Marina V Aksenova, Justin Sybrandt, Biyun Cui, Vitali Sikirzhytski, Hao Ji, Diana Akinyi Odhiambo, Matthew D. Lucius, Jill R Turner, Eugenia V. Broude, Edsel A. Peña, Sofia B. Lizarraga, Jun Zhu, Ilya Safro, Michael D. Wyatt, Michael S. Shtutman
This study identifies DDX3 inhibition as a potential therapy for HAND by blocking Tat and cocaine-induced microglial activation and neurotoxicity in rat and mouse models.
Journal of Neuroimmune Pharmacology · Dec 4, 2019Peer-reviewedNeuroscience