Author

Eugenia V. Broude

University of South CarolinaORCID 0000-0002-9180-7111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Diana Akinyi OdhiamboiD· 2 shared Marina V AksenovaiD· 2 shared Michael D. WyattiD· 2 shared Michael S. ShtutmaniD· 2 shared Vitali SikirzhytskiiD· 2 shared Aliaksandra SikirzhytskayaiD· 1 shared Alissa Richmond ArmstrongiD· 1 shared B. Celia CuiiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Diana Akinyi OdhiamboORCID

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3 papers

Recent·Most cited

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson, Katie L. Kathrein, Alissa Richmond Armstrong, Robert Michael Gower, Igor B. Roninson, Eugenia V. Broude, Mengqian Chen, Hao Ji, Chang‐Uk Lim, Hongjun Wang, Daping Fan, Peisheng Xu, Jie Li, , Hexin Chen

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

npj Breast Cancer · Jan 17, 2026Peer-reviewedCancer Biology

Suppression of HIV and cocaine-induced neurotoxicity and inflammation by cell penetrable itaconate esters

B. Celia Cui, Marina V Aksenova, Aliaksandra Sikirzhytskaya, Diana Akinyi Odhiambo, Elizaveta Korunova, Vitali Sikirzhytski, Hao Ji, Diego Altomare, Eugenia V. Broude, Norma Frizzell, Rosemarie M. Booze, Michael D. Wyatt, Michael S. Shtutman

This paper shows that 4-octyl-itaconate reduces HIV and cocaine-induced neurotoxicity and inflammation by modulating microglial activity and anti-inflammatory pathways.

bioRxiv · Sep 25, 2023 · PreprintNeuroscience

Inhibition of the Dead Box RNA Helicase 3 prevents HIV-1 Tat and cocaine-induced neurotoxicity by targeting microglia activation

Marina V Aksenova, Justin Sybrandt, Biyun Cui, Vitali Sikirzhytski, Hao Ji, Diana Akinyi Odhiambo, Matthew D. Lucius, Jill R Turner, Eugenia V. Broude, Edsel A. Peña, Sofia B. Lizarraga, Jun Zhu, Ilya Safro, Michael D. Wyatt, Michael S. Shtutman

This study identifies DDX3 inhibition as a potential therapy for HAND by blocking Tat and cocaine-induced microglial activation and neurotoxicity in rat and mouse models.

Journal of Neuroimmune Pharmacology · Dec 4, 2019Peer-reviewedNeuroscience