A novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity
Vera Nickl, Julian Hübner, Marah Alsalkini, Rhonda L. McFleder, Julia A. Wagner, Renato Liguori, Björn Grams, Moritz Meyer-Hofmann, Leopold Diener, Camelia Maria Monoranu, Carsten Hagemann, Fulvia Ferrazzi, Chi Wang Ip, Ralf‐Ingo Ernestus, Hermann Einsele, , Thomas Nerreter
This paper develops a PDPN- and GD2-targeting CAR T cell blend to overcome glioblastoma heterogeneity, showing improved anti-tumor activity in organoids and increased survival in mice.
bioRxiv · Feb 3, 2025 · PreprintImmunology