Thomas Nerreter

The paper develops an optimized immunolabeling protocol to quantify endogenous membrane receptor stoichiometry using single-molecule localization microscopy on Jurkat T cells and primary multiple myeloma cells.

This paper develops a PDPN- and GD2-targeting CAR T cell blend to overcome glioblastoma heterogeneity, showing improved anti-tumor activity in organoids and increased survival in mice.

The paper shows that tumor-derived glucocorticoids increase ROR1 expression while suppressing T cell activity, and GC-resistant CAR-T cells can overcome this by preserving ROR1 expression in tumor cells.