Hermann Einsele

Integrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host-pathogen dynamics during Aspergillus fumigatus infection

This study validates an alveolar-like macrophage model as a physiologically relevant in vitro system for studying early Aspergillus fumigatus infection dynamics.

Tumor-tropic E. coli engineered as living T and NK cell engagers

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

M-CSF stimulated alveolar macrophages safeguard from invasive aspergillosis

This study shows that M-CSF enhances alveolar macrophage function to protect against invasive aspergillosis in immunocompromised mice.

Profound CD4+ T-Cell Reprogramming by Melphalan-Driven Oxidative Stress in High-Risk Multiple Myeloma

This study shows that melphalan treatment causes oxidative stress in T cells, reducing CD4+ naive T cells in high-risk multiple myeloma patients.

Single-molecule localization microscopy reveals the molecular organization of endogenous membrane receptors

The paper develops an optimized immunolabeling protocol to quantify endogenous membrane receptor stoichiometry using single-molecule localization microscopy on Jurkat T cells and primary multiple myeloma cells.

Secondary lymphoid organ endothelial cells prime alloreactive CD4+ T cells to trigger acute graft-versus-host disease

This study identifies blood endothelial cells in secondary lymphoid organs as key APCs that prime donor CD4 T cells, leading to acute graft-versus-host disease.

Unveiling immune interference: How the dendritic cell response to co-infection with Aspergillus fumigatus is modulated by human cytomegalovirus and its virokine CMVIL-10

This study investigates how HCMV and its virokine CMVIL-10 modulate dendritic cell responses during co-infection with A. fumigatus, revealing that CMVIL-10 has a limited role in suppressing antifungal immunity.

A novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity

This paper develops a PDPN- and GD2-targeting CAR T cell blend to overcome glioblastoma heterogeneity, showing improved anti-tumor activity in organoids and increased survival in mice.

Tumour-derived glucocorticoids amplify ROR1 and are exploited with glucocorticoid-resistant ROR1 CAR-T cells

The paper shows that tumor-derived glucocorticoids increase ROR1 expression while suppressing T cell activity, and GC-resistant CAR-T cells can overcome this by preserving ROR1 expression in tumor cells.

Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.