Metadata Collector is an open-source platform designed to standardize metadata management in multi-centre sequencing projects, ensuring FAIR-aligned and reproducible metadata across distributed research groups.

bioRxiv · Jun 8, 2026 · PreprintBioinformatics

Macrophages foster adaptive anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction

Kathrin Fuchs, Elisabetta D’Avanzo, Isabell Armstark, Ruthger van Roey, Ana Clavel Ezquerra, Nino Bindel, Katharina Siebenkäs, Yussuf Hajjaj, Renato Liguori, Fulvia Ferrazzi, Lukas Amon, Johanna Bulang, Julian Hübner, Marcel Edler, Ece Grace, , Harald Schuhwerk

This study identifies ZEB1 as a key regulator of TAM-mediated T cell trafficking, enhancing CTL recruitment and immunosurveillance in tumors and metastases.

Communications Biology · Jul 1, 2025Peer-reviewedCancer Biology

A novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity

Vera Nickl, Julian Hübner, Marah Alsalkini, Rhonda L. McFleder, Julia A. Wagner, Renato Liguori, Björn Grams, Moritz Meyer-Hofmann, Leopold Diener, Camelia Maria Monoranu, Carsten Hagemann, Fulvia Ferrazzi, Chi Wang Ip, Ralf‐Ingo Ernestus, Hermann Einsele, , Thomas Nerreter

This paper develops a PDPN- and GD2-targeting CAR T cell blend to overcome glioblastoma heterogeneity, showing improved anti-tumor activity in organoids and increased survival in mice.

bioRxiv · Feb 3, 2025 · PreprintImmunology