Macrophage-Derived PDGF-BB and GDF-15 Promote Drug Resistance in KRAS-Mutant Colorectal Cancer
Bjork S. Aston, Hammed A. Badmos, Ross Leigh Cagan
This study identifies macrophage-derived PDGF-BB and GDF-15 as mediators of drug resistance in KRAS-mutant colorectal cancer organoids and shows that targeting tyrosine kinase signaling can restore drug sensitivity.
bioRxiv · Apr 27, 2026 · PreprintCancer Biology