Ross Leigh Cagan

This study identifies macrophage-derived PDGF-BB and GDF-15 as mediators of drug resistance in KRAS-mutant colorectal cancer organoids and shows that targeting tyrosine kinase signaling can restore drug sensitivity.

This study uses Drosophila models to explore how specific genetic mutations in Nigerian colorectal cancer patients affect drug responses, showing that treatment efficacy depends on tumor genotype.

This study identifies anastrozole's off-target CYP4V2 as a neuroprotective factor in tauopathy models by reducing Tau phosphorylation and oxidative stress.

This study shows that WNT signaling enhances NF-κB activation and drug resistance in KRAS-mutant colorectal cancer, suggesting a therapeutic strategy targeting WNT and MEK pathways.

The paper identifies glucuronidation pathway upregulation as a mechanism by which colon cancer cells develop resistance to trametinib, showing that inhibiting this pathway can reverse resistance in both Drosophila and mouse models.

This paper shows rigosertib reverses hypertrophic cardiomyopathy in RAF1-associated Noonan syndrome using Drosophila, iPSC, and mouse models.

The paper identifies 48 functional driver genes from copy number alterations in a Drosophila TNBC model and shows their role in increased therapeutic resistance.

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

The paper develops a platform combining Drosophila models and computational methods to identify novel chemicals targeting a kinase network in Medullary Thyroid Cancer.