Distinct effects of disease-associated TREM2 R47H/+ and T66M mutations on iPSC-derived microglia.
Jay Penney, William T. Ralvenius, Anjanet R. Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Hannah Woolf, Li‐Huei Tsai
This study compares the effects of TREM2 R47H/+ and T66M mutations on iPSC-derived microglia, finding distinct gene expression and functional changes linked to neurodegeneration.
bioRxiv · Oct 5, 2022 · PreprintNeuroscience