Attenuated estrogen signaling disrupts placentation and drives trophoblast defects in Down syndrome
Deirdre M. Logsdon, Isabela Tiemy Pereira, Kindyll Wetta, Lauren S. Ohler, Mika Nevo, Bo Thorstenson, Brian F. Niemeyer, Bilge Birsoy, Lynae Smith, Cameron Hebert, John L. Rinn, Matthew D. Galbraith, Mary Ann Allen, Robin D. Dowell, Joaquin Maximiliano Espinosa, , Justin Brumbaugh
This study identifies attenuated estrogen signaling and NRIP1 as key factors in trophoblast defects in Down syndrome using patient-derived stem cells.
bioRxiv · Jun 8, 2026 · PreprintDevelopmental Biology