The paper identifies the regulatory roles of the CCR4-NOT complex in mRNA deadenylation and decay by analyzing transcriptome-wide effects of subunit depletion.

bioRxiv · Oct 2, 2026 · PreprintBiochemistry

Attenuated estrogen signaling disrupts placentation and drives trophoblast defects in Down syndrome

Deirdre M. Logsdon, Isabela Tiemy Pereira, Kindyll Wetta, Lauren S. Ohler, Mika Nevo, Bo Thorstenson, Brian F. Niemeyer, Bilge Birsoy, Lynae Smith, Cameron Hebert, John L. Rinn, Matthew D. Galbraith, Mary Ann Allen, Robin D. Dowell, Joaquin Maximiliano Espinosa, , Justin Brumbaugh

This study identifies attenuated estrogen signaling and NRIP1 as key factors in trophoblast defects in Down syndrome using patient-derived stem cells.

bioRxiv · Jun 8, 2026 · PreprintDevelopmental Biology

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Patrizia Pessina, Mika Nevo, Junchao Shi, Srikanth Kodali, Eduard Casas, Yingzhi Cui, Alicia Richards, Emily J. Park, Xi Chen, Florencia Levin-Ferreyra, Alejandra Rivera Tostado, Erica J. Stevenson, Nevan J. Krogan, Danielle L. Swaney, Qi-Long Ying, , Bruno Di Stefano

The paper profiles RNA content in P-bodies across vertebrate species, showing that RNA sequestration in condensates is linked to cell fate transitions through miRNA-dependent mechanisms.

Nature Biotechnology · Oct 28, 2025Peer-reviewedCell Biology