Author
Case Western Reserve University
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Mohammed R. Alzahrani, Bo‐Jhih Guan, Leah L. Zagore…·Maria Hatzoglou
The paper investigates how newly synthesized mRNA, specifically XBP1 mRNA, escapes translational repression during the acute phase of the UPR by accumulating long poly(A) tails, enhancing cell survival.
Chien-Wen Chen, Bo‐Jhih Guan, Mohammed R. Alzahrani…·Maria Hatzoglou
This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.
Raul Jobava, Yuanhui Mao, Bo‐Jhih Guan…·Maria Hatzoglou
The paper shows that cells use an adaptive pausing response to survive severe stress by pausing translation and limiting ATP use, followed by recovery through ISR signaling.