Author

Raul Jobava

Case Western Reserve University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Maria HatzoglouiD· 3 shared Bo‐Jhih Guan· 2 shared Chien-Wen CheniD· 2 shared Donny D. LicatalosiiD· 2 shared Leah L. ZagoreiD· 2 shared Zhaofeng GaoiD· 2 shared Ajay H. ZalavadiaiD· 1 shared Aleksandra TrifunovićiD· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMolecular Biology

Maria HatzoglouORCID

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Author profile →

3 papers

Recent·Most cited

Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

Chien-Wen Chen, Bo‐Jhih Guan, Mohammed R. Alzahrani, Zhaofeng Gao, Long Gao, Syrena Bracey, Jing Wu, Cheikh A. Mbow, Raul Jobava, Leena Haataja, Ajay H. Zalavadia, Ashleigh E. Schaffer, Hugo Lee, Thomas LaFramboise, Ilya R. Bederman, , Maria Hatzoglou

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

Nature Communications · Aug 8, 2022Peer-reviewedSystems Biology

Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

Raul Jobava, Yuanhui Mao, Bo‐Jhih Guan, Di Hu, Dawid Krokowski, Chien-Wen Chen, Xin Erica Shu, Evelyn Chukwurah, Jing Wu, Zhaofeng Gao, Leah L. Zagore, William C. Merrick, Aleksandra Trifunović, Andrew Caleb Hsieh, Saba Valadkhan, , Maria Hatzoglou

The paper shows that cells use an adaptive pausing response to survive severe stress by pausing translation and limiting ATP use, followed by recovery through ISR signaling.

Molecular Cell · Oct 1, 2021Peer-reviewedMolecular Biology

Dazl regulates germ cell survival through a network of polyA proximal mRNA interactions

Leah L. Zagore, Thomas J. Sweet, Molly M. Hannigan, Sebastien M. Weyn‐Vanhentenryck, Raul Jobava, Maria Hatzoglou, Chaolin Zhang, Donny D. Licatalosi

This study identifies Dazl's role in germ cell survival by mapping its RNA interactions and showing its regulation of genes critical for proliferation and survival.

Cell Reports · Oct 1, 2018Peer-reviewedMolecular Biology