Chien-Wen Chen

The paper investigates how newly synthesized mRNA, specifically XBP1 mRNA, escapes translational repression during the acute phase of the UPR by accumulating long poly(A) tails, enhancing cell survival.

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

The paper shows that cells use an adaptive pausing response to survive severe stress by pausing translation and limiting ATP use, followed by recovery through ISR signaling.