A Preoptic Neurocircuit That Modulates Metabolic Flexibility
Julian M. Roessler, Matthew Alkire, Nathan T Nigrin, Haorui Wang, Christopher M. Reid, Marissa D. Cortopassi, Millenia Waite, Brooke Linnehan, Eric C. Griffith, Mollie Madigan, Tenzin Kunchok, Alexander S. Banks, Fabian Schulte, Bukyung Kim, Bo-Yeon Kim, , Siniša Hrvatin
The paper identifies a preoptic neurocircuit that modulates metabolic flexibility by shifting fuel use from glucose to fatty acids through insulin resistance in skeletal muscle.
bioRxiv · Feb 14, 2026 · PreprintNeuroscience