Fibroblast-Enhanced Tumour Microenvironment Signalling Promotes Adaptive Doxorubicin Tolerance in Heterotypic Melanoma Spheroids
I Pavel, Giorgiana Negrea, Marta Szilvia Meszaros, Valentin Florian Rauca, Bogdan Razvan Dume, Emilia Licărete, Laura Pătraș, Stefan Dragan, Vlad Alexandru Toma, Alina Sesărman, Manuela Banciu
This study shows fibroblasts in melanoma spheroids enhance doxorubicin tolerance by altering transcriptional responses, promoting stress-adaptive states over classical resistance mechanisms.
bioRxiv · Jul 1, 2026 · PreprintCancer Biology