Alina Sesărman

Extracellular Vesicles Derived from Activated Dendritic Cells Loaded with Curcumin Promote Early Activation-associated Functional and Molecular Reprogramming of Primary CD8+ T Cells

This study shows that curcumin-loaded dendritic cell-derived extracellular vesicles enhance early activation of CD8+ T cells by promoting effector-like phenotypes and sustained molecular reprogramming.

Fibroblast-Enhanced Tumour Microenvironment Signalling Promotes Adaptive Doxorubicin Tolerance in Heterotypic Melanoma Spheroids

This study shows fibroblasts in melanoma spheroids enhance doxorubicin tolerance by altering transcriptional responses, promoting stress-adaptive states over classical resistance mechanisms.

A QbD strategy to develop curcumin and siRNA co-loaded lipoplexes to combat osteoarthritis-related inflammation and oxidative stress

This paper develops co-loaded lipoplexes using QbD principles to deliver curcumin and siRNA for treating osteoarthritis by reducing inflammation and oxidative stress.

Exploring the mechanisms of early acquired resistance to doxorubicin in melanoma spheroids

This study examines how melanoma spheroids develop early resistance to doxorubicin through adaptive molecular changes, including upregulated angiogenesis and cell migration.