Fibroblast-Enhanced Tumour Microenvironment Signalling Promotes Adaptive Doxorubicin Tolerance in Heterotypic Melanoma Spheroids
I Pavel, Giorgiana Negrea, Marta Szilvia Meszaros…·Manuela Banciu
This study shows fibroblasts in melanoma spheroids enhance doxorubicin tolerance by altering transcriptional responses, promoting stress-adaptive states over classical resistance mechanisms.