Author

Valentin Florian Rauca

Babeș-Bolyai UniversityORCID 0000-0002-5879-9308Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alina SesărmaniD· 2 shared Emilia LicăreteiD· 2 shared Giorgiana NegreaiD· 2 shared Laura PătrașiD· 2 shared Manuela BanciuiD· 2 shared Stefan DraganiD· 2 shared Vlad Alexandru TomaiD· 2 shared Bogdan Razvan Dume· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

Alina SesărmanORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Fibroblast-Enhanced Tumour Microenvironment Signalling Promotes Adaptive Doxorubicin Tolerance in Heterotypic Melanoma Spheroids

I Pavel, Giorgiana Negrea, Marta Szilvia Meszaros, Valentin Florian Rauca, Bogdan Razvan Dume, Emilia Licărete, Laura Pătraș, Stefan Dragan, Vlad Alexandru Toma, Alina Sesărman, Manuela Banciu

This study shows fibroblasts in melanoma spheroids enhance doxorubicin tolerance by altering transcriptional responses, promoting stress-adaptive states over classical resistance mechanisms.

bioRxiv · Jul 1, 2026 · PreprintCancer Biology

Exploring the mechanisms of early acquired resistance to doxorubicin in melanoma spheroids

Giorgiana Negrea, Ilie Ovidiu Pavel, Loredana Bălăcescu, Bogdan-Razvan Dume, Emilia Licărete, Valentin Florian Rauca, Laura Pătraș, Szilvia Meszaros, Stefan Dragan, Vlad Alexandru Toma, Manuela Banciu, Alina Sesărman

This study examines how melanoma spheroids develop early resistance to doxorubicin through adaptive molecular changes, including upregulated angiogenesis and cell migration.

bioRxiv · Apr 7, 2025 · PreprintCancer Biology