Analysis of Confounding Factors in Reactive Cysteine Profiling Reveals Enhanced Chromatin-Protein Association via CDK7 Inhibition by THZ1
Ka Yang, Shaoxian Li, Bohui Li, Daniel M. Richards, Kevin Dong, Uthpala I. Seneviratne, Wankyu Lee, Anthony A. Iannetta, Hua Xu, Steven P. Gygi, Qing Yu
This study compares cysteine ligandability in live cells and native lysates, identifying factors like accessibility, abundance, and relocalization, and shows THZ1 induces chromatin binding.
ACS Chemical Biology · May 29, 2026Peer-reviewedCell Biology