Ka Yang

This study compares cysteine ligandability in live cells and native lysates, identifying factors like accessibility, abundance, and relocalization, and shows THZ1 induces chromatin binding.

This paper develops a human lymphoid follicle chip platform to model intramuscular mRNA vaccine responses, showing it can replicate immune responses to both naive and recall antigens.

The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

The paper presents Turnover-PPT, a resource mapping protein and phosphoprotein turnover across mouse tissues and brain regions, revealing tissue-specific protein lifetimes and phosphorylation's impact on stability.