Mitochondrial complex I as a diagnostic and therapeutic target in a mouse model of tauopathy
Jia Hui Wong, Anselm Salvatore Vincent, Shivashankar Khanapur, Tang Jun Rong, Boominathan Ramasamy, Siddesh V. Hartimath, Peter K.C. Cheng, Hideo Tsukada, Edward George Robins, Julian Goggi, Anna M. Barron
This study uses MC-I-PET to assess mitochondrial dysfunction in a tauopathy mouse model and evaluates the therapeutic effects of Mdivi-1, finding no rescue of mitochondrial deficits despite tau reduction and harmful effects of Mdivi-1.
bioRxiv · Aug 13, 2023 · PreprintNeuroscience