Anna M. Barron

Interaction between mitochondrial translocator protein and aging in inflammatory responses in mouse hippocampus

This study examines how aging interacts with TSPO's immunomodulatory role in mouse hippocampus, showing aging reverses TSPO knockout effects and exacerbates inflammation.

Defective lysosomal acidification contributes to TNFR1 mediated neuronal necroptosis in Alzheimer's disease

This study shows defective lysosomal acidification contributes to TNFR1-mediated neuronal necroptosis in Alzheimer's disease and demonstrates that lysosome-acidifying nanoparticles can rescue this process.

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

Mitochondrial complex I as a diagnostic and therapeutic target in a mouse model of tauopathy

This study uses MC-I-PET to assess mitochondrial dysfunction in a tauopathy mouse model and evaluates the therapeutic effects of Mdivi-1, finding no rescue of mitochondrial deficits despite tau reduction and harmful effects of Mdivi-1.

Mitochondrial control of microglial phagocytosis in Alzheimer's disease

This study shows that TSPO regulates mitochondrial metabolism and phagocytosis in microglia, and that targeting mitochondrial HK could improve phagocytosis in Alzheimer's disease.

Tracking tau fibrillogenesis and consequent primary phagocytosis of neurons mediated by microglia in a living tauopathy model

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.