Jia Hui Wong

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

This study uses MC-I-PET to assess mitochondrial dysfunction in a tauopathy mouse model and evaluates the therapeutic effects of Mdivi-1, finding no rescue of mitochondrial deficits despite tau reduction and harmful effects of Mdivi-1.

This study shows that TSPO regulates mitochondrial metabolism and phagocytosis in microglia, and that targeting mitochondrial HK could improve phagocytosis in Alzheimer's disease.