NeurosciencebioRxivPreprint
Mitochondrial complex I as a diagnostic and therapeutic target in a mouse model of tauopathy
Jia Hui Wong, Anselm Salvatore Vincent, Shivashankar Khanapur…·Anna M. Barron
This study uses MC-I-PET to assess mitochondrial dysfunction in a tauopathy mouse model and evaluates the therapeutic effects of Mdivi-1, finding no rescue of mitochondrial deficits despite tau reduction and harmful effects of Mdivi-1.