Avoidance of pyroptosis accounts for the relatively high metastatic potential observed in early hybrid EMT states
Aakanksha Verma, Alessandro Genna, Yaron Vinik, Nishanth Belugali Nataraj, Maha Abedrabbo, Boobash Raj Selvadurai, Tithi Bhandari, Noa Aharoni, Palaniappan Ramesh, Boris Boguslavski, Diana Drago Garcia, Tomer‐Meir Salame, Amir Pri-Or, Yishai Levin, Eviatar Weizman, , Yosef Yarden
The paper identifies Arrdc4's role in suppressing pyroptosis in biphenotypic EMT cells, linking its downregulation to increased metastatic potential and poor prognosis in breast cancer.
bioRxiv · Jan 26, 2025 · PreprintCancer Biology