Author

Yosef Yarden

Weizmann Institute of Science

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Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Alessandro GennaiD· 3 shared Diana Drago GarciaiD· 3 shared Nishanth Belugali NatarajiD· 3 shared Sima LeviD· 3 shared Arunachalam SekariD· 2 shared Boobash Raj SelvaduraiiD· 2 shared Carlos CaldasiD· 2 shared Eviatar WeizmaniD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Alessandro GennaORCID

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3 papers

Recent·Most cited

Inducible re-epithelialization of cancer cells increases autophagy and DNA damage: implications for breast cancer dormancy

Diana Drago Garcia, Suvendu Giri, Rishita Chattaerjee, Arturo Simoni Nieves, Maha Abedrabbo, Alessandro Genna, Mary Luz Uribe Rios, Moshit Lindzen, Arunachalam Sekar, Nitin Gupta, Noa Aharoni, Tithi Bhandari, Agalyan Mayalagu, Luisa E. Schwarzmüller, Nooraldeen Tarade, , Yosef Yarden

The paper shows that inducing epithelial traits in breast cancer cells increases autophagy and DNA damage, potentially contributing to tumor dormancy and reactivation.

bioRxiv · Feb 9, 2025 · PreprintCancer Biology

Avoidance of pyroptosis accounts for the relatively high metastatic potential observed in early hybrid EMT states

Aakanksha Verma, Alessandro Genna, Yaron Vinik, Nishanth Belugali Nataraj, Maha Abedrabbo, Boobash Raj Selvadurai, Tithi Bhandari, Noa Aharoni, Palaniappan Ramesh, Boris Boguslavski, Diana Drago Garcia, Tomer‐Meir Salame, Amir Pri-Or, Yishai Levin, Eviatar Weizman, , Yosef Yarden

The paper identifies Arrdc4's role in suppressing pyroptosis in biphenotypic EMT cells, linking its downregulation to increased metastatic potential and poor prognosis in breast cancer.

bioRxiv · Jan 26, 2025 · PreprintCancer Biology

TMPRSS2-ERG confers resistance to antiandrogens: mechanism and therapeutic implications

Arunachalam Sekar, Rishita Chatterjee, Boobash Raj Selvadurai, Lipika R. Pal, Aakanksha Verma, Nishanth Belugali Nataraj, Diana Drago Garcia, Suvendu Giri, Alessandro Genna, Feride Karatekin, Nitin Gupta, Mirie Zerbib, Yaron Vinik, Tamir Avioz, Eviatar Weizman, , Yosef Yarden

This study shows that TMPRSS2-ERG fusion promotes resistance to antiandrogens by interacting with GR, suggesting combined GR and AR inhibition could benefit tERG-positive prostate cancer patients.

bioRxiv · Jan 17, 2025 · PreprintCancer Biology