Yishai Levin

This study identifies a small molecule targeting PSME4, which stabilizes STAT1 and reprograms tumor inflammation, suppressing tumor growth by altering cytokine signaling.

This study identifies CD45 as a tuft cell-intrinsic checkpoint that limits intestinal type 2 immunity through an IL-13-induced negative feedback mechanism.

This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.

The paper shows that insular cortex activity predicts glucose homeostasis by driving anticipatory insulin release and metabolic regulation.

The paper identifies two opposing redox signals mediated by 2-Cys peroxiredoxins that regulate metabolic pathways during photosynthetic induction in plants.

This study shows that LIS1 mutations in brain organoids lead to increased tissue stiffness and altered ECM structure, with a computational model predicting mechanical changes.

This study investigates the molecular interactions between SNX10, CLC-7, and OSTM1 in osteoclasts, showing they regulate lysosome distribution and fusion during osteoclastogenesis.

This study translates post-mortem brain multi-omics AD dementia subtypes into blood, MRI, and psychological markers in living individuals.

The paper identifies and characterizes non-genetic and genetic protein variants in human proteomes, showing they contribute to functional diversity.

The paper identifies Arrdc4's role in suppressing pyroptosis in biphenotypic EMT cells, linking its downregulation to increased metastatic potential and poor prognosis in breast cancer.

This paper introduces a CRISPR-based platform to study GABARAP proteins in autophagy, revealing their distinct associations with autophagosomes.

This study shows that ERBB2 activates YAP signaling through phosphorylation, driving EMT-like processes and cardiac regeneration in mice after injury.

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.