Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage
Ying Liu, Tansol Choi, Brad Pearson, Ryan Nachman, Whitney Woo, Na Xu, Ryan P. Schreiner, Romulo Hurtado, Marco Seandel, Shahin Rafii, Todd Evans
This study shows that SPRY4-ERK signaling acts as a checkpoint to restore spermatogenesis after germline stem cell damage, with its loss leading to impaired regeneration and fertility.
Biology of Reproduction · Mar 19, 2026Peer-reviewedCell Biology