Todd Evans

Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type

This study identifies Scleraxis a as a key regulator of epicardial progenitor differentiation into a unique cardiac perivascular cell type in zebrafish, revealing a hypoxia-responsive pathway involved in coronary vessel development.

Engineering a pacemaker-driven human mini-heart guided by spatial multi-omics of sinoatrial node development

This paper develops a pacemaker-driven human mini-heart using spatial multi-omics and stem-cell engineering to study cardiac conduction and drug discovery.

3D Imaging with Superior Resolution Using Atacama Clear

This paper introduces Atacama Clear (ATC), a 3D imaging technology that improves resolution and signal detection in cleared tissues, enabling better analysis of complex biological samples.

Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage

This study shows that SPRY4-ERK signaling acts as a checkpoint to restore spermatogenesis after germline stem cell damage, with its loss leading to impaired regeneration and fertility.

GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling

This study shows GATA6 mediates endoderm and mesoderm progenitor fate by integrating NODAL and WNT signaling during gastrulation.

GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

This study shows GATA6 regulates WNT and BMP programs in human precardiac mesoderm patterning, and modulating these pathways can rescue cardiomyocyte defects in GATA6 mutants.

Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection

The paper develops vascularized macrophage-islet organoids to study immune-mediated β cell pyroptosis during viral infection and identifies TNFSF12-TNFRSF12A as a key mechanism.

Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm

This study identifies OTX2 as a critical regulator of definitive endoderm specification and gut patterning through chromatin remodeling and signaling pathway regulation.

Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem Cells

The paper shows that adding lipid-rich albumin to 2i media maintains genomic stability and developmental potency of murine pluripotent stem cells over long-term culture.