Shahin Rafii

This study shows MYC drives endothelial transformation and dedifferentiation in angiosarcoma by promoting lineage plasticity and cell growth.

This study generates hypoimmunogenic gastric insulin-secreting organoids (GINS) and shows PD-L1 engineering improves their survival under immune challenge.

This study uses spatial imaging to identify architectural changes in bone marrow that predict disease activity and response to therapy in myelodysplastic neoplasms.

This study shows that SPRY4-ERK signaling acts as a checkpoint to restore spermatogenesis after germline stem cell damage, with its loss leading to impaired regeneration and fertility.

The paper identifies MTA2 and SATB2 as a chromatin complex that maintains colonic identity by retaining HNF4A on colonic chromatin, preventing plasticity toward small intestine.

The paper identifies rare fetal liver HSCs with unique features like differentiation latency and dormancy signatures using single cell RNA-sequencing and a niche-mimicking culture platform.

This study identifies transcription factors that induce vascular blood stem cell niches in vivo, enabling synthetic niche generation and potential therapeutic applications.

The paper shows that multipotent progenitors and HSC arise from distinct HE populations during mouse embryogenesis, identified through clonal assays and single-cell transcriptomics.

The paper identifies key signaling molecules involved in HSC development by analyzing single-cell transcriptomics data from AGM-derived cells and uses them to engineer a supportive niche for HSC generation.