Cell BiologybioRxiv
HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis
Cagla Cömert, Kasper Kjær-Sørensen, Jakob Hansen…·Peter Bross
This study investigates how HSP60 deficiency disrupts mitochondrial proteostasis and dysregulates cholesterol synthesis, leading to developmental abnormalities and hypomyelination.
DOI 10.1016/j.molmet.2024.102009