Johan Palmfeldt

The paper develops a SorCS2-derived macrocycle, TT-P34, which shows neuroprotective effects in animal models of neurodegeneration by enhancing mitochondrial function and reducing disease symptoms.

This study shows that thymic Treg-derived T follicular regulatory cells prevent autoimmunity by limiting GC responses during TLR7-driven inflammation.

This paper develops SORTACs, small molecules that degrade extracellular proteins by hijacking the sortilin/progranulin interaction, showing nanomolar potency against TNFα.

This study uses a rat model to show that MuSK autoimmunity causes fiber-type-selective muscle atrophy and proteome remodeling, with mitochondrial and translational dysregulation as key features.

The paper assesses protein recovery from alkali-treated EPS in activated sludge, finding keratin dominates due to its resistance to Maillard reactions, while bacterial proteins are modified and less recoverable.

This study identifies TGM2 as a predictive marker of hepatic steatosis improvement in obese mice infected with H. p. bakeri, showing its role in type 2 immune responses and potential therapeutic applications.

This study identifies a novel role for SORLA in regulating exosome release and neurotrophic function, linking SORL1 mutations to Alzheimer's disease pathology.

This study shows carbonic anhydrase inhibitors prevent capillary flow issues in a mouse model of early Alzheimer's disease before symptoms appear.

This study investigates how HSP60 deficiency disrupts mitochondrial proteostasis and dysregulates cholesterol synthesis, leading to developmental abnormalities and hypomyelination.

The paper identifies circZNF827 as a repressor of neuronal differentiation by forming a transcription-inhibitory complex with hnRNP-K/L proteins and modulating NGFR expression.

This study investigates the role of BRD1 in sex-biased nuclear receptor signaling and its implications in mental disorders using mouse models and gene expression analysis.