Claus Oxvig

This study identifies SorCS2 as a regulator of Wnt signaling homeostasis by controlling Ror2 trafficking and signaling, with implications for neurodevelopment.

The paper shows lactating serum has anti-cancer effects targeting PAPP-A-expressing cells and identifies CRF as a key mediator of this effect through mitochondrial inhibition.

This study investigates how HSP60 deficiency disrupts mitochondrial proteostasis and dysregulates cholesterol synthesis, leading to developmental abnormalities and hypomyelination.

This study identifies SorCS2 as a receptor for progranulin that regulates motor axon outgrowth in zebrafish and mice, with loss-of-function phenotypes observed in both species.

The paper identifies Papp-aa as a [Ca2+]-regulated molecular switch that links IGF signaling to ionocyte reactivation and bone calcification in zebrafish.