Case Study of High-Throughput Drug Screening and Remote Data Collection for SARS-CoV-2 Main Protease by Using Serial Femtosecond X-ray Crystallography
Ömür Güven, Mehmet Gül, Esra Beyarslan Ayan, J Austin Johnson, Barış Çakilkaya, Gozde Usta, Fatma Betül Ertem, Nurettin Tokay, Büşra Yüksel, Oktay Göcenler, Cengizhan Büyükdağ, Sabine Botha, Gihan K. Ketawala, Zhen Su, Brandon Hayes, , Hasan DeMi̇rci̇
This study demonstrates a high-throughput drug screening protocol using serial femtosecond X-ray crystallography for SARS-CoV-2 main protease, achieving 120 images/second with a new detector.
Crystals · Dec 17, 2021Peer-reviewedMolecular Biology