XDH-1 inactivation causes xanthine stone formation in C. elegans which is inhibited by SULP-4-mediated anion exchange in the excretory cell
Jennifer Snoozy, Sushila Bhattacharya, Brandon Johnson, Robin R. Fettig, Ashley Van Asma, Chloe Brede, Sophia G. Miller, Martina Ralle, Kurt Warnhoff
This paper identifies sulp-4 as a critical gene controlling xanthine stone accumulation in C. elegans by mediating sulfate transport, and shows its interaction with sulfur amino acid metabolism and osmotic stress pathways.
PLoS Biology · Sep 24, 2025Peer-reviewedGenetics