Martina Ralle

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

The paper investigates metal homeostasis changes in quiescent cells induced by different triggers and finds trigger-specific remodeling of metal pools and associated gene expression.

This paper identifies MKV3 as the first small-molecule inhibitor of Cu+-transporting P1B-type ATPases, showing broad activity across species and defining a conserved Cu+ entry pocket for drug development.

This paper identifies sulp-4 as a critical gene controlling xanthine stone accumulation in C. elegans by mediating sulfate transport, and shows its interaction with sulfur amino acid metabolism and osmotic stress pathways.

The paper shows that SLC30A10 deficiency leads to increased manganese absorption via iron transporters SLC11A2 and SLC40A1, contributing to manganese excess and disease.