Kurt Warnhoff

Paralogous guanine deaminases acquired from bacteria by horizontal gene transfer promote purine homeostasis in Caenorhabditis elegans

This study identifies two paralogous guanine deaminases in C. elegans that regulate purine homeostasis, with one acquired via horizontal gene transfer from bacteria.

XDH-1 inactivation causes xanthine stone formation in C. elegans which is inhibited by SULP-4-mediated anion exchange in the excretory cell

This paper identifies sulp-4 as a critical gene controlling xanthine stone accumulation in C. elegans by mediating sulfate transport, and shows its interaction with sulfur amino acid metabolism and osmotic stress pathways.

Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans

The paper identifies a feedback loop where high cysteine levels activate HIF-1 to induce cdo-1, promoting cysteine degradation via an H2S signaling pathway in C. elegans.

Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans

The paper shows that protein-bound molybdenum cofactor (Moco) is bioavailable and rescues Moco-deficient C. elegans, suggesting a new therapeutic strategy for human Moco deficiency.