Author

Brenda J Chen

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:C. elegans· 1 Approach:experimental assay· 1

Frequent Co-Authors

Irini TopalidouiD· 1 shared Katherine S. YanagiiD· 1 shared Nicolas J. LehrbachiD· 1 shared Sheikh Omar KunjoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMolecular Biology

Irini TopalidouORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Lysine deficiency within a conserved lysine desert is critical for EEL-1/HUWE1 to support ubiquitin proteasome system function.

Katherine S. Yanagi, Brenda J Chen, Sheikh Omar Kunjo, Irini Topalidou, Nicolas J. Lehrbach

This study identifies the critical role of lysine deficiency in EEL-1/HUWE1 for maintaining UPS function by enhancing ubiquitination of pre-ubiquitinated substrates.

PLoS Genetics · Aug 10, 2026Peer-reviewedMolecular Biology