Nicolas J. Lehrbach

Lysine deficiency within a conserved lysine desert is critical for EEL-1/HUWE1 to support ubiquitin proteasome system function.

This study identifies the critical role of lysine deficiency in EEL-1/HUWE1 for maintaining UPS function by enhancing ubiquitination of pre-ubiquitinated substrates.

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation

This study shows tioxazafen is bioactivated by cytochrome P450s into a proteasome disruptor, leading to toxicity in nematodes and potential human skin reactions.

Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans

The paper identifies previously unknown Scm3/HJURP orthologs in metazoans using remote homology, structural modeling, and functional genetics, revealing their conserved role in centromere function despite sequence divergence.

Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2.

The paper shows that sequence editing of SKN-1A/Nrf1 regulates its transcriptomic output, revealing distinct and overlapping functions with SKN-1C/Nrf2 in stress responses.

Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility

The paper identifies two CSR-1 isoforms in C. elegans and shows they have distinct roles in fertility and immunity.