Irini Topalidou

This study identifies the critical role of lysine deficiency in EEL-1/HUWE1 for maintaining UPS function by enhancing ubiquitination of pre-ubiquitinated substrates.

This study shows tioxazafen is bioactivated by cytochrome P450s into a proteasome disruptor, leading to toxicity in nematodes and potential human skin reactions.

The paper identifies previously unknown Scm3/HJURP orthologs in metazoans using remote homology, structural modeling, and functional genetics, revealing their conserved role in centromere function despite sequence divergence.

The paper shows that sequence editing of SKN-1A/Nrf1 regulates its transcriptomic output, revealing distinct and overlapping functions with SKN-1C/Nrf2 in stress responses.

The paper identifies new proteins involved in apical ECM biology in C. elegans and shows SYM-3/FAM102A and SYM-4/WDR44 function in trafficking but not ECM protein deposition.

This study identifies GRK-2 as a regulator of exploration and movement quiescence in C. elegans by acting in chemosensory neurons and opposing neuropeptide signaling pathways.

This study identifies a pathway linking the dopamine receptor DOP-1 to a sleep mechanism that modulates sustained swimming in C. elegans.

This study identifies the ERK MAPK pathway as a modulator of Gq-Rho signaling in C. elegans, affecting locomotion behavior through head acetylcholine neurons.

This study identifies a pathway by which dopamine modulates NCA channel activity in C. elegans through Gq-Rho and GRK-2 signaling.

This study identifies the sek-1 p38 MAPK pathway as a regulator of Gq signaling and locomotion in C. elegans through genetic and behavioral analyses.

This study identifies NCA-1 and NCA-2 as downstream targets of the Gq/Rho pathway in C. elegans, showing their role in regulating locomotion through neuronal activity.

This paper identifies EIPR-1 and the EARP complex as conserved factors required for dense-core vesicle cargo sorting in C. elegans and rat cells.