Brendan Charles

Adaptation of fluorescence rescue reporters of mistranslation for use in Saccharomyces cerevisiae

This paper adapts a fluorescence-based method to detect mistranslation in yeast and shows it detects mistranslation events differently than mass spectrometry.

Varied forms of mutant tRNA mistranslation produce distinct phenotypes across multiple model organisms

This study investigates how different tRNA mutations lead to varied toxic phenotypes across organisms, finding that amino acid property changes and mistranslation frequency are key factors.

Mistranslating tRNA variants have anticodon- and sex-specific impacts on Drosophila melanogaster

This study examines the effects of two mistranslating tRNA variants in Drosophila melanogaster, showing sex-specific impacts on development, lifespan, and locomotion.

A Novel Mistranslating tRNA Model in Drosophila melanogaster has Diverse, Sexually Dimorphic Effects

This paper introduces a Drosophila melanogaster model with a mistranslating tRNA variant, showing it causes developmental delays, reduced adult viability, and sexually dimorphic morphological and behavioral effects.