Joshua Isaacson

This study shows that mistranslation in Drosophila melanogaster females increases lifespan, even when reproduction is involved, contradicting the expectation that proteotoxic stress would reduce longevity.

This study examines the effects of two mistranslating tRNA variants in Drosophila melanogaster, showing sex-specific impacts on development, lifespan, and locomotion.

The paper compares the transcriptional response of male and female Drosophila melanogaster to proline-to-serine mistranslation, identifying sex-specific gene expression changes and their implications for disease and tRNA therapeutics.

This paper introduces a Drosophila melanogaster model with a mistranslating tRNA variant, showing it causes developmental delays, reduced adult viability, and sexually dimorphic morphological and behavioral effects.

This paper develops an inducible tRNA system to study mistranslation effects in yeast by regulating tRNA expression through RNA polymerase II promoters.

This study compares the effects of two tRNA variants causing different amino acid substitutions in yeast, showing distinct impacts on growth, heat shock response, and transcriptome changes.

The paper identifies genes with chemical-genetic interactions with AZC in yeast, revealing pathways involved in coping with amino acid mis-incorporation and proteotoxic stress.