Cell-Intrinsic Vulnerability and Immune Activation Cooperate to Drive Degeneration in a Mitochondrial Complex I Deficiency Model of Optic Neuropathy
Daniela Santamaría-Muñoz, Raenier V. Reyes, Miranda R. Krueger, Andrea García‐Llorca, Brennan Marsh-Armstrong, Xin Duan, Yang Hu, Derek S. Welsbie, Nicholas Marsh‐Armstrong, Elisenda Sanz, Albert Quintana, Sergi Simó, Anna La Torre
This study investigates how mitochondrial dysfunction and immune activation contribute to retinal ganglion cell degeneration in optic neuropathy using transgenic models.
Journal of Neuroinflammation · Feb 6, 2026Peer-reviewedNeuroscience