Xin Duan

WTR is a toolkit for functional anterograde transneuronal circuit mapping using a fusion protein that labels and manipulates downstream neurons.

The paper identifies a hypothalamic-hindbrain circuit in mice that suppresses excretion and pelvic pain during movement, enhancing mate-seeking behavior.

The paper maps thalamic inputs onto molecularly defined cortical neurons in mice, revealing a visual hierarchy through bottom-up and top-down signatures.

This paper introduces a 3D imaging and analysis framework to study retinal microvasculature, revealing layer-associated vulnerability in vascular development and neovascular remodeling.

The paper identifies a circuit involving DLS Pdyn neurons that links contextual cues to feeding regulation through inhibition of LHA GABAergic neurons.

This study investigates how mitochondrial dysfunction and immune activation contribute to retinal ganglion cell degeneration in optic neuropathy using transgenic models.

This study shows that Afadin is essential for sorting retinal neuron types into correct cellular layers, but not for their survival or synaptic partner selection.

This paper develops a method to rapidly generate ventral A9-like dopaminergic neurons from iPSCs using small molecules and Ascl1 expression, creating functional 3D organoids for Parkinson's disease research.

The paper identifies Cdh6 as a marker for a novel class of sensory neurons in the mouse colon that regulate colonic motility through specific electrophysiological properties and functional responses.

This study identifies OPTN's role in axonal mitochondria transport and shows its loss contributes to neurodegeneration in models of ALS and NTG.

This study maps the molecular and cellular dynamics of the developing human neocortex using single-nucleus data, revealing gene regulatory networks and a cancer-related progenitor subtype.

The paper maps the spatial distribution of retinal ganglion cell types and identifies perivascular RGCs that show neuroprotection after optic nerve injury.

The paper shows that hippocampal neurogenesis remodeling causes forgetting by altering engram accessibility, using genetic and optogenetic manipulations in mice.

This study identifies a kappa opioid signaling pathway that regulates ependymal cell proliferation in the spinal cord, with implications for scar formation and injury recovery.

This study shows that coordinated cadherin activity in respiratory motor neurons and interneurons is essential for proper circuit connectivity and breathing function.

The paper shows that estrogen enhances activity in melanocortin neurons, reducing sedentary behavior and linking estrogen signaling to metabolic regulation.

This study uses scRNA-Seq to analyze human and mouse retinal development, identifying conserved and species-specific gene expression patterns and a novel role for ATOH7 in photoreceptor specification.

The paper maps transgene insertion sites in mice and shows that transgene integration affects neighboring endogenous gene expression.

This study uses single-cell RNA-seq to analyze human fetal retinal development, revealing transcriptional programs and developmental trajectories of retinal cell types.