Yang Hu

Closed-loop optical optimization enables patterned retinal stimulation in vivo at cellular scales

This paper introduces a closed-loop optical platform for precise retinal stimulation in mice, achieving high-resolution patterned stimulation with real-time focus correction.

Cell-Intrinsic Vulnerability and Immune Activation Cooperate to Drive Degeneration in a Mitochondrial Complex I Deficiency Model of Optic Neuropathy

This study investigates how mitochondrial dysfunction and immune activation contribute to retinal ganglion cell degeneration in optic neuropathy using transgenic models.

Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers

This study shows that Afadin is essential for sorting retinal neuron types into correct cellular layers, but not for their survival or synaptic partner selection.

GPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection

This study shows that GPX4 overexpression in RGCs promotes optic nerve regeneration and neuroprotection in glaucoma models.

Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

This study identifies OPTN's role in axonal mitochondria transport and shows its loss contributes to neurodegeneration in models of ALS and NTG.

Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques

This paper establishes a rhesus macaque model of glaucomatous neurodegeneration using silicone oil injection, showing RGC death, optic nerve degeneration, and functional deficits similar to human glaucoma.

Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy

This paper develops a cold-protective treatment for traumatic optic neuropathy using a clinically relevant animal model, showing that combined hypothermia and cold protection reduces inflammation and metabolic stress without cellular damage.

Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17

This study shows that ZDHHC17 couples DLK and NMNAT2 pathways to control both somal and distal axon degeneration after optic nerve crush.

Silicone oil-induced ocular hypertension in mouse models glaucomatous neurodegeneration and neuroprotection

This paper develops a reversible mouse model of secondary glaucoma using silicone oil and validates it for testing neuroprotective therapies.